Androgen receptor (AR) expression in different Gleason scores of prostatic adenocarcinoma by immunohistochemistry

Background: Prostatic cancer is highly ominous in men and survives hormonal insufficiency. We studied Androgen Receptor (AR) expression various Gleason scores (GS) of prostatic adenocarcinoma by using immunohistochemistry.
 Materials methods: This descriptive analytical study was carried out at King Edward Medical University/Mayo Hospital, Lahore 2016. Slides were prepared from 60 paraffin blocks stained for evaluation different parameters like score (GS), histopathological grades (well differentiated, intermediate or high grade) AR immunohistochemistry score. Data entry analysis SPSS version 22. The relationship between determined Pearson chi-square test. A p-value < 0.05 considered statistically significant.
 Results: Out cases, 15 (25%) had 45 (75%) grade tumors. positive 59 (98.33%) cases. Among the 5 (8.33%) +1 score, 25 (41.67%) has +2 29 (48.33%) +3 significant association with GS histological found.
 Conclusion: positivity significantly associated Score grading prostate adenocarcinoma, hence it may prove a useful diagnostic prognostic marker carcinoma prostate.